Protein Details: Two pore potassium channel a

Protein ID

ICDB_Pro_1194

Protein Name

Two pore potassium channel a

Gene Name

TPKA; KCO1; Os03g0752300; LOC_Os03g54100; OJ1112_G08.7; OsJ_12594; OSJNBa0032E21.10; OSJNBa0047E24.7

Organism

Oryza sativa subsp. japonica (Rice)

Length

347 amino acids

AlphaFoldDB

AF-Q850M0-F1-model_v4.pdb

Function

Highly selective inward-rectifying potassium channel that is specifically located in the tonoplast of large vacuoles. Functions independently of the voltage difference across the membrane.

Sequence

MDDNSIQQSLLADNPNVLQRKPSEGVNRFRRCRSTPSTDPLQGPPEKGSSVKAKELFKEMRPSFRLVGLLLFIYLLVGVLAFYAVMDEISGKRTNRVLDALYFCVVTMTTVGYGDLVPNNDTTKLLACAFVFMGMAVVALFVSKVADYLVEKQEVLFFKALHTNLKGGETKMLRAIETNRIKYKFYTNALLLVLSIISGTVFLWKVEKLSLVDSFYCVCATITTLGYGDKSFSSKLGRVFAVFWIITSTIIMAQFFMYLAEIYTERRQKMLANWVLTRKMTKMDLEAADLDDDRQVGAAEFVVYKLKELGKINQEEISSFLEEFEKLDVDHSGTLSPYDLTLAQSAQ

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

289;291;293;295;300;328;330;332;334;339

Disease

Location

DOI ID

10.1101/gr.3869505; 10.1038/nature03895; 10.1093/nar/gkm978; 10.1186/1939-8433-6-4; 10.1371/journal.pbio.0030038; 10.1126/science.1081288; 10.1105/tpc.110.081463

RefSeq

XP_015630528.1; XP_015630529.1; XP_015630530.1; XP_015630531.1